Trps1 breast
WebJun 12, 2024 · The TRPS1 gene is very often amplified in breast cancer (28% of 2051 cases in the METABRIC cohort and 20% of 963 patients in the TCGA cohort) and its amplification is associated with worse ... WebApr 3, 2024 · TRPS1 (trichorhinophalangeal syndrome type 1) is a transcription factor of the GATA family, and has been found to be a relatively specific marker of breast cancers through TCGA (The Cancer Genome Atlas) data mining [].It is not only expressed in a high proportion of ER-positive or HER2-positive BCs, but also in TNBCs of different types, …
Trps1 breast
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WebIn the current study, through TCGA data mining we identified trichorhinophalangeal syndrome type 1 (TRPS1) as a specific gene for breast carcinoma across 31 solid tumor types. Moreover, high mRNA level of TRPS1 was found in all four subtypes of breast carcinoma including ER/PR-positive luminal A and B types, HER2-positive type, and basal … WebThe association between YAP1 and TRPS1 was primarily clarified by Elster et al, who suggested that YAP1 was downregulated, while TRPS1 was commonly amplified in breast cancer, and high TRPS1 activity was associated with decreased YAP1 activity, leading to decreased frequency of tumor-infiltrating immune cells. 15 Therefore, the present study ...
WebMar 1, 2024 · TRPS1 has been recently demonstrated as a highly sensitive and specific marker for breast carcinomas. To further explore TRPS1's utility in breast carcinoma, we … WebTRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer Highlights • Poorly differentiated human cancers have limited shared epigenomic dependencies • TRPS1 is a breast lineage-specific transcriptional dependency • TRPS1 is required for normal mitosis by directly regulating genes in G2-M •
WebTRPS1 gene was responsible for most of the TRPS phenotype; Data show that co-silencing of tricho-rhino-phalangeal-syndrome (TRPS1) and cathepsin D (Cath-D) in breast cancer … WebBone is a frequently implicated organ in metastatic breast cancer, and approximately 70% of metastatic breast cancer patients suffer from bone metastases 68. miR-30 family members are involved in breast cancer bone metastases, but their roles remain controversial. Some scholars believe that miR-30 family members employ multiple mechanisms to ...
WebNov 18, 2024 · TRPS1 is a sensitive and specific marker for metastatic breast cancer in serous effusion cell-block specimens. It shows superior sensitivity and specificity compared with GATA3, especially in the TNBC setting and for excluding urothelial carcinoma. CONFLICTS OF INTEREST The authors made no disclosures.
WebJan 31, 2013 · Moreover, Trps1 has been found to be closely related to tumorigenesis, invasion, and metastasis in prostate and breast cancers. It is interesting to note that during the development of hair follicles, bones, and kidneys, mutations in Trps1 cause, either directly or through crosstalk with other regulators, a notable change in cell proliferation ... cfo niti book pdfWebAug 10, 2024 · Involved in breast cancer carcinogenesis and required for breast cancer cell survival Plays a critical role in the development of cartilage, bone and hair follicle ... by5256WebJul 3, 2024 · The GATA transcription factor TRPS1 is abnormally up-regulated in breast cancer, osteosarcoma, prostate cancer, and other tumor tissues, and is instrumental in … cfo nintendo of americaWebTRPS1 is commonly amplified in breast cancer, which suggests that restrained YAP activity favours tumour growth. High TRPS1 activity is associated with decreased YAP activity and leads to decreased frequency of tumour-infiltrating immune cells. Our study uncovers TRPS1 as an epigenetic regulator of YAP activity in breast cancer. by5250WebOct 3, 2024 · In the current study, through TCGA data mining we identified trichorhinophalangeal syndrome type 1 (TRPS1) as a specific gene for breast carcinoma across 31 solid tumor types. Moreover, high... cfonline cardfactory.co.ukWebNov 11, 2024 · In this study, overexpression of lncRNA178030.2 significantly attenuated the inhibitory effect of 1 μM paclitaxel in cell proliferation of MDA-MB-231, while knockdown of lncRNA178030.2 had an opposite effect, suggesting that lncRNA178030.2 mediated the process of paclitaxel resistance of breast cancer cells. TRPS1 is a newly discovered … cf on mumsnetWebTrichorhinophalangeal syndrome type 1 (TRPS1) Immunostain, Technical Component Only Overview Specimen Clinical & Interpretive Performance Fees & Codes Setup & Updates Useful For Identification of breast carcinoma including triple negative breast cancer Reflex Tests Testing Algorithm by5255