Polymer effect on cocrystal dissolution
WebNov 27, 2024 · The present study was aimed to understand the impact of polymeric additives on dissolution of thermodynamically highly unstable cocrystal with specific …
Polymer effect on cocrystal dissolution
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http://hs.link.springer.com.dr2am.wust.edu.cn/article/10.1007/s10118-023-2916-4?__dp=https WebThis Reprint Book is a collection of articles that show the utility of pharmaceutical cocrystals and various aspects of cocrystal research: • Cocrystals as a strategy to modify the …
WebApplicability of phenolic acids as potential cocrystal formers for methylxanthine derivatives was analyzed both in terms of cocrystallization probabilities and solubility advantage. The … WebThe objectives of this study were to demonstrate the importance of experimental set-up and type of coformer for the enhanced dissolution properties of cocrystals. Carbamazepine …
WebThanks to a chance interaction between Chailu Que and Qingqing Qi in the NMR room, we were able to develop a collaboration and synthesize some structural… WebThe dissolution results showed that the release of curcumin in solid dispersion outperformed the release rate of pure curcumin, where the release of solid dispersion …
WebA structural analysis of cocrystals, solid solutions and eutectics has led to an understanding that materials with strong adhesive (hetero) interactions between the unlike components will lead to cocrystals whereas those having stronger cohesive (homo/self) interactions will more often give rise to solid solutions (for similar structures of components) and …
WebOct 22, 2024 · The effects of surfactants and polymers on the solubility and dissolution of TEC-HBA cocrystals under sink and nonsink conditions were then investigated. (3) … flowline lc09-2014WebThe purpose of this study was to discriminate three crystal forms of carbamazepine (a BCS II drug) by in vitro dissolution testing and to correlate in vitro data with published in vivo data. A biphasic dissolution system (phosphate buffer pH 6.8 and octanol) was used to evaluate the dissolution of the three polymorphic forms and to compare it with … flowline ld34WebThe present study was aimed to understand the impact of polymeric additives on dissolution of thermodynamically highly unstable cocrystal with specific emphasis on influence of drug–polymer interactions. Exemestane-maleic acid was selected as a model cocrystal with SMPT time of <30 s and eutectic constant (Keu) of 75475. flowline lc30WebAnother way to increase the API’s dissolution rate is to use amphiphilic polymers such as surfactants (Figure 4) to enhance the wetting of the API within the gastrointestinal tract, … flowline lc10-1002WebApr 20, 2016 · Preformulation - polymorph, salt, & cocrystal screening; solubilization; solid-state stability; discovery support. Formulation development - powder compaction & flow … flowline lc10-1001WebThe formation of cocrystallization in two various conjugated components may endow the newly formed conjugated cocrystals with multiple functionalities and improved charge transport properties. However, compared to conjugated small molecules, this strategy is rather limitedly realized in conjugated polymers. Herein, a simple meniscus-assisted … flowline lc42WebSolhe F. Alshahateet was born in Irbed, Jordan on May 21st, 1969. He is a Professor of Organic and Supramolecular Chemistry graduated in 2003 from the University of New … flowline ld30-s211