Irf7 phosphorylation
WebIRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 … WebIRF7 is synthesized as a latent protein and is posttranslationally modified by protein phosphorylation in infected cells. Phosphorylation required a carboxyl-terminal regulatory …
Irf7 phosphorylation
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WebIRF7, once induced, is present in the cytoplasm as an inactive protein that is also phosphorylated on specific C-terminal residues by TBK1 and/or possibly IKKε kinases ( Fitzgerald et al., 2003; Sharma et al., 2003 ). IRF7 has an important role in the regulation of IFNA genes other than A4. WebNov 18, 2024 · IRF3 and IRF7 are critical transcription factors in the innate immune response. Their activation is controlled by phosphorylation events, leading to the …
WebJan 8, 2024 · Therefore, we identified novel function of Zdhhc2 in controlling inflammatory response in psoriasis in mice and we also confirmed that crucial role of Zdhhc2 in pDCs by regulating IRF7 activity and production of the critical cytokine. WebIRF-7 plays an essential role in the induction of type I interferon in response viral infection (6-8). Like IRF-3, IRF-7 is regulated at multiple serine phosphorylation sites near its …
WebApr 14, 2011 · IRF7 is a lymphoid-specific factor, which is constitutively expressed in the cytoplasm in B cells, pDCs and monocytes in the spleen, thymus, and peripheral blood lymphocytes, and is potently... WebA, kinetics of IRF7 phosphorylation. 293T cells transfected with 10 μg of an IRF7 expression construct were infected with NDV 12 h later, and nuclear extracts harvested at the …
WebMar 29, 2024 · In pDCs in which the TLR7/TLR9 pathway is predominantly active, phosphorylation and activation of IRF7 is independent of TBK1/IKKε and instead involves recruitment of MyD88, recruitment and activation of IRAK1/2/4 signaling complex, resulting in IKKα activation and phosphorylation of IRF7, thus driving IFN-α/β expression in …
grant writing for government agenciesWebApr 2, 2024 · SAMHD1 also interacts with the inhibitor-κB kinase ε (IKKε) and IFN regulatory factor 7 (IRF7), leading to the suppression of the IFN-I induction pathway by reducing IKKε-mediated IRF7 phosphorylation. Interactions of endogenous SAMHD1 with NF-κB and IFN-I pathway proteins were validated in human monocytic cells and primary macrophages. chippable woodWebApr 4, 2024 · Interferon regulatory factor 7 (IRF7) is a direct target of miR-762 and overexpression of miR-762 reduced expression of IRF7. Data indicate that the type-I … grant writing for health careWebsignaling pathways downstream of PRRs lead tothe phosphorylation of IFN regulatory factor 7 (IRF7) and IRF3, thus promoting their di-merization and translocation to the nucleus where they activate the transcription of type I IFN genes. IRF3 and IRF7 share some structural and functional similarities, grant writing for local governmentWebThe study suggests that activation of IRF7 is more stringent than the activation of IRF3 (38). Mechanistically, IRF3 only requires phosphorylation of the 2S site for activation, whereas IRF7 ... grant writing for librariesWebNov 7, 2016 · Phosphorylation of IRF7 is necessary for IFN- α signal transduction, followed by nuclear translocation and activation of type I IFN gene transcription [ 7, 8 ]. However, when the expression of type I IFN is dysregulated, adverse immunological effects may result. grant writing formats templatesWebAug 11, 2009 · IRF3 and IRF7 activation is mediated by a wide range of phosphorylation events, many of which are directly induced by the IKK-related kinases to coordinate protein dimerization, nuclear translocation, DNA binding, and the induction of IFNβ [8,20-24]. chippa charity