WebOct 19, 2024 · It has been demonstrated that activation of NF-κB signaling contributes to the development of cardiac hypertrophy. 16 Immunoblotting of left ventricle tissue isolates from WT TAC-operated mice showed increased phosphorylation of NF-κB pathway factors IKKα/β, IκBα, and p65 at 2 and 8 weeks postinjury. WebGata4. Status. UniProtKB reviewed (Swiss-Prot) Organism. Rattus norvegicus (Rat) Amino acids. 440. Protein existence. Evidence at protein level. Annotation score. 5/5. ... CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. Interacts with NR5A1, ZFPM2 and TBX5. Interacts with ZNF260. Interacts with TBX18 …
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WebMar 15, 2024 · Acetylation of H3K9 and H3K27 has also been suggested to be involved in the expression of GATA4, as GATA4 is involved in the development of HF and the fetal gene is reactivated during HF, suggesting that the acetylation of H3K4 may be involved in cardiac hypertrophy and HF (25, 26). WebAug 10, 2001 · GATA4 DNA Binding Activity Is Augmented by Hypertrophic Agonist Stimulation To investigate the role of GATA factors as hypertrophic regulators, we first examined whether expression of GATA4 or GATA6 was altered by hypertrophic stimuli.
WebAug 4, 2024 · In our study, GATA4 is upregulated in ISO-induced hypertrophy model and 24-month old rats, which could serve as an indicator for the heart aging. Although the specificity of GATA4 in heart aging is still need to be further investigated, it somewhat directs the future research in exploring the markers to identify the aging and hypertrophy. WebTranscriptional synergy based on protein-protein interaction involving GATA4 and these transcriptional factors may be implicated in the …
WebHasegawa et al. (1997) concluded that interaction between GATA4 and the GATA element plays a role in the transcriptional activation of MYH7 during pressure overload cardiac hypertrophy. Similar evidence implicating GATA4 as a mediator of cardiac hypertrophy was presented by Herzig et al. (1997). WebMar 31, 2006 · Role of Gene Expression Reprogramming in the Transition to Cardiac Dysfunction. In response to hypertrophic stimuli, adult cardiomyocytes reactivate the fetal gene regulatory program and downregulate various adult isoforms. 11 Re-expression of the GATA4-regulated genes ANP, BNP, and β-MHC is considered a hallmark of pathological …
WebApr 19, 2024 · Gesine M. Dittrich,#1,2,8Natali Froese,1Xue Wang,#1,3Hannah Kroeger,1Honghui Wang,1Malgorzata Szaroszyk,1Mona Malek-Mohammadi,2,8Julio Cordero,4Merve Keles,2Mortimer Korf-Klingebiel,1Kai C. Wollert,1Robert Geffers,5Manuel Mayr,6Simon J. Conway,7Gergana Dobreva,4,8Johann Bauersachs,1and Joerg …
WebThe inhibition of p300-dependent acetylation of GATA4 suppresses the transcription of cardiac hypertrophic response genes, cardiomyocyte hypertrophy, and the development of heart failure, suggesting that regulation of the transcriptional activity of GATA4 could serve as a novel therapeutic strategy for heart failure [11, 12]. new leaf institute owasso okWeb上海康朗生物科技有限公司主要致力于“Anti-GATA4抗体”的生产销售。多年的“Anti-GATA4抗体”生产与销售的经验，与各行业新老用户建立了稳定的合作关系，我公司经营的产品名称深受广大用户信赖。欢迎来电咨询或前来选购。 联系电话：021-61998208。 newleaf international ltdWebDec 31, 2013 · These results indicate that GATA-4 and GATA-6 play a dosage-dependent and redundant role in programming cardiac hypertrophy, but that each has a more complex role in maintaining cardiac homeostasis and resistance to heart failure following injury that cannot be compensated by the other. new leaf inspections• Evans T, Reitman M, Felsenfeld G (1988). "An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes". Proc. Natl. Acad. Sci. U.S.A. 85 (16): 5976–80. Bibcode:1988PNAS...85.5976E. doi:10.1073/pnas.85.16.5976. PMC 281888. PMID 3413070. • Huang WY, Cukerman E, Liew CC (1995). "Identification of a GATA motif in the cardiac alpha-myosin heavy-chain-encoding gene and isolation of a human GATA-4 cDN… new leaf internationalWebJun 28, 2024 · Unlike from our previous findings, here, NEU1 plays a non-canonical role as a co-activator to interact with transcriptional factors GATA4, promoting cardiac hypertrophy and remodelling. This study combined with our previous work showed that NEU1 is a key driver of cardiovascular disease, and is therefore a potential therapeutic target. intm169010WebAug 5, 2024 · The lysosomal inhibitor bafilomycin A1 increases the levels of GATA4 at the basal state (Fig 5C and 5D), suggesting that GATA4 is constitutively degraded by autophagy. It remains to be determined why this is the case. GATA4 is an evolutionarily conserved transcription factor that is crucial for development of the heart, liver, and … intm 180010WebFeb 26, 2024 · the acetylation of GATA4 as one of critical nuclear events in myocardial cell hypertrophy. Increased GATA4 protein degradation may be an important mechanism that contributes to hyperglycemic cardiotoxicity. GATA-4 is a novel downstream effector of … new leaf insurance