Cisplatin hearing loss thesis

Author: fdtw

August undefined, 2024

WebJun 1, 2024 · Hearing loss likely occurs in all cancers that are treated with cisplatin. Cisplatin is the most ototoxic drug in clinical use. It also happens to be a fantastic … WebNov 21, 2024 · Cisplatin chemotherapy causes permanent hearing loss in 40-80% of treated patients. It is unclear whether the cochlea has unique sensitivity to cisplatin or is exposed to higher levels of the drug. Here we use inductively coupled plasma mass spectrometry (ICP-MS) to examine cisplatin pharmacokinetic …

Sodium thiosulfate for prevention of cisplatin-induced hearing loss ...

WebFeb 11, 2024 · Cisplatin is a highly effective chemotherapeutic drug used against a wide range of childhood and adult cancers, but cisplatin … WebSynthese und Charakterisierung von neuen Dicobalthexacarbonyl-Komplexen als Cycl... 9 Referenzen [1] Titelblatt bims tool

CISPLATIN-INDUCED OTOTOXICITY. PHARMACOKINETICS, …

WebJun 3, 2024 · The topic of my MSc thesis work was “Synthesis and Characterization of CuO-PVA Nanofluid for Heat Transfer Applications”. ... Cisplatin-induced ototoxicity (CIO), manifests as permanent, bilateral, high frequency sensorineural hearing loss that is estimated to affect 26-90% of children that has debilitating effects on children’s ... WebThe impact of hearing loss can be devastating and is often associated with tinnitus, imbalance, or a debilitating sensitivity to sound. Cisplatin is commonly used with curative intent. As such, protecting the patient’s quality of life after cisplatin chemotherapy should be of high interest to both physicians and patients. cyperus cephalanthus

A Study of Treatment for Medulloblastoma Using Sodium …

Cisplatin and Hearing Loss: Until Now, an Unquantified Risk

WebJun 21, 2024 · Hearing loss of grade 1 or higher occurred in 18 of 55 children (33%) in the cisplatin–sodium thiosulfate group, as compared with 29 of 46 (63%) in the cisplatin-alone group, indicating a 48% ... WebMar 24, 2014 · Detailed Description: The study is a dose-finding study of N-acetylcysteine (NAC) to protect hearing in children receiving cisplatin for the treatment of their cancer. NAC also has potential to protect the kidneys from cisplatin toxicity. The study uses a 3+3 dose-escalation scheme to determine the dose of NAC necessary to achieve serum … bims technologiesWebThe incidence of ototoxicity induced by cisplatin ranges from 20% to 70%, and it usually manifests as a progressive, bilateral and irreversible hearing loss. Although the etiology … cyperus beans

"WebJan 25, 2024 · More than half of patients treated with cisplatin-based chemotherapy develop hearing loss or tinnitus, which can be devastating, say researchers who urge … " - Cisplatin hearing loss thesis

Cisplatin hearing loss thesis

Cisplatin ototoxicity: Examination of the impact of dosing, …

WebJan 25, 2024 · More than half of patients treated with cisplatin-based chemotherapy develop hearing loss or tinnitus, which can be devastating, say researchers who urge that all patients should be tested routinely. WebJan 1, 2024 · Cisplatin-induced hearing loss is permanent, and there are currently no FDA-approved therapies to reduce or prevent cisplatin ototoxicity. Here we explore the …

Did you know?

WebJan 1, 2024 · Atorvastatin use significantly reduces the odds of a clinically meaningful cisplatin-induced hearing loss. An analysis of the incidence of a CTCAE-defined hearing loss due to cisplatin therapy in the full cohort and key subgroups is shown. For the full cohort and the subject subgroups, the difference in the incidence (% of ears) and 95% CI … WebCisplatin-Induced Hearing Loss Childhood Cancer Hearing Loss Patient Focused Drug Development (PFDD) Meeting The pediatric patient population with chemotherapy …

WebNov 29, 2024 · Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): A multicentre, randomised, controlled, open-label, phase 3 ... WebSep 24, 2024 · As cisplatin is an effective treatment for cancer, researchers have focused on finding ways to counteract the associated hearing loss. Combination therapies, where a protective compound (otoprotectant) such as antioxidants, anti-inflammatories, and steroids are administered alongside cisplatin, aim at decreasing the probability of the patient ...

WebApr 1, 2011 · As has proven to be the case with noise-induced hearing loss and age-related hearing loss, oxidative stress has a key role in cisplatin ototoxicity. Additionally, like with noise and aging, apoptotic cell death has been identified as the primary mode of cell death in cochleae exposed to cisplatin. WebApr 17, 2024 · For patients treated with the chemotherapeutic drug cisplatin, one common consequence of treatment is permanent hearing loss. Reported rates of cisplatin …

WebMay 19, 2024 · Cisplatin may cause hearing loss as a side effect. In the average-risk medulloblastoma patients, this trial tests whether the addition of sodium thiosulfate (STS) to standard of care chemotherapy and radiation therapy reduces hearing loss. Previous studies with STS have shown that it may help reduce or prevent hearing loss caused by …

WebCisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of this … bims thaimassagenWebDec 18, 2024 · December 18, 2024. Scientists have found a new way to explain the hearing loss caused by cisplatin, a powerful drug used to treat many forms of cancer. Using a highly sensitive technique to measure and map cisplatin in mouse and human inner ear tissues, researchers found that forms of cisplatin build up in the inner ear. cyperus actaWebhearing loss observed is typically irreversible, progressive, bilateral, high-frequency sensorineural hearing loss associated with tinnitus. At present there is no approved … bims testing scoreWebApr 26, 2024 · 1 In a recent study, most patients (388 of 488, 80%) had a hearing loss of at least 20 dB and 40% suffered from tinnitus. 2 Sixty-three to 77% of children 3 4 suffer permanent sensorineural hearing loss from cisplatin chemotherapy. Cisplatin primarily affects the high frequencies in both ears and is permanent. cypert sealeWebHigh-dose cisplatin treatment: hearing loss and plasma concentrations. Fifty-four patients with metastatic cancer were followed audiometrically during high-dose (100-120 mg/m2) … bims testing in nursing homesWebJul 3, 2024 · Cisplatin-induced hearing loss is associated not only with dosage, but also with the administration protocol. Whether used in single high dose or multiple low dose, … bimstec host country 2021WebSep 4, 2024 · Scientists have found out why Cisplatin causes hearing loss. Cisplatin is a powerful drug used in some chemotherapy treatments to treat many forms of cancer. … cyperus brevifolioides